Tissue plasminogen activator is a potent activator of PDGF-CC
نویسندگان
چکیده
منابع مشابه
Tissue plasminogen activator is a potent activator of PDGF-CC.
Tissue plasminogen activator (tPA) is a serine protease involved in the degradation of blood clots through the activation of plasminogen to plasmin. Here we report on the identification of tPA as a specific protease able to activate platelet-derived growth factor C (PDGF-C). The newly identified PDGF-C is secreted as a latent dimeric factor (PDGF-CC) that upon proteolytic removal of the N-termi...
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Platelet-derived growth factor C (PDGF-C) is one of four members in the PDGF family of growth factors, which are known mitogens and survival factors for cells of mesenchymal origin. PDGF-C has a unique two domain structure consisting of an N-terminal CUB and a conserved C-terminal growth factor domain, that are separated by a hinge region. PDGF-C is secreted as a latent dimeric factor (PDGFCC) ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2004
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7600397